Australia, at the break before a bumper Gabba crowd cheering them on in Brisbane, were 228-3 after the visitors collapsed to be all out for 334 in their first innings following Joe Root’s epic unbeaten 138.
Steve Smith was not out 24 and Cameron Green unbeaten on 22 as Australia battled their way through a tough twilight session, losing two wickets after England’s bowlers found their rhythm.
Weatherald, playing just his second test, hammered 12 boundaries and a six in an aggressive knock before he was trapped lbw by Jofra Archer with an angled yorker.
Labuschagne — Australia’s in-form batsman over the last six months with a host of centuries in domestic cricket — was equally composed as shadows fell across the ground and bowlers got more movement.
But just when he appeared to be on course for another ton, England captain Ben Stokes gave his team the key breakthrough when he edged one through to wicketkeeper Jamie Smith.
Dangerman Travis Head, Australia’s sledgehammer hero in the first Test win at Perth, was out for 33 before tea.
England lost their final wicket of Root in the second over of the day.
They had left off at 325-9 after he had taken them from the depths of 5-2 with his maiden hundred on Australian soil and 40th overall in a gripping day one.
He and Archer added nine to the overnight score before number 11 fell for a career-best 38, caught by a diving Labuschagne in the deep off Brendan Doggett.
It was the end to a priceless 10th-wicket stand of 70, an England record last wicket stand at the Gabba.
Starc, a veteran left-arm quickie, claimed 6-75 to pass Pakistani Wasim Akram as the most successful left-arm fast bowler in Test history.
Head bludgeoned a 69-ball hundred as Australia thrashed England by eight wickets in Perth.
But he was a little more circumspect this time around after being recalled as opener for the injured Usman Khawaja.
It took him 15 balls to get started but not before a huge reprieve on three when Smith grassed an absolute sitter off an outside edge from Archer.
He was woken up by the scare and proceeded to let rip in the next over, knocking 4-6-3, though his luck ran out when he nicked one high to Gus Atkinson off Brydon Carse — England sighed gently as walked off.
He was soon into his groove, with a flurry of early boundaries, cuts and drives coming naturally to him.
Three of them arrived in five balls from Atkinson as the outfield sped away and he got to an eye-catching 50 from 45 with a single, but then Archer spun it around.
Labuschagne was able to continue, moving passed a 25th test half-century from the previous day on his way to 65 with 10 boundaries.